Bromelain: Effect on amoxicillin?

The most popular treatments consist of two antibiotics (one of which is usually clarithromycin) plus a strong acid blocker such as omeprazole (PriLosec, Nexium, Somac, Zoton, etc.). Treatment is for 7-10 days. Cure rate is about 85%

Moderators: Toni, barjammar, luci2010, Ondek-Expert, kkimura

Post Reply
eliuri
Posts: 11
Joined: Tue Feb 19, 2019 8:10 am

Bromelain: Effect on amoxicillin?

Post by eliuri » Thu Feb 28, 2019 2:20 am

Hello:

I usually take the supplement Bromelain to help with inflammation.

I've just read several medical articles which assert that Bromelain can potentiate Amoxicillin (and Tetracycline) and increase its levels in blood. In fact, it is often used to do just that.

My concern is that it might also increase its side-effects. Especially since I'm now taking 2 grams of it daily.

However , I also read-in journal article- that it can decrease side-effects of these antibiotics, as well as potentiating them:

===================

"Bromelain increases bioavailability and reduces the side effects that are associated with various antibiotics (12,13)"[


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998156/



[cut and paste above link into browser for it to work]

==================

So far , this is only source I have found for reducing side effects. Much of the literature only references increasing blood levels of Amoxicillin.

An article surveying the medical literature on Bromelain does discuss its potentiating effects on some antibiotics and does discuss a study where some who failed to respond to antibiotics for diverse conditions (H.Pylori wasnt among them in that particular study) did succeed when the antibiotic was combined with Bromelain. Here's reference to that survey of the literature:

Bromelain: A Literature Review and
Discussion of its Therapeutic Applications
by: Gregory S Kelly

(Alt Med Rev 1996;1(4):243-257)

=============================

So... I'm wondering if I really should be discontinuing Bromelain during the course of this triple therapy? It is a useful supplement for me.

Thank you

Helico_expert
Site Admin
Posts: 3507
Joined: Wed Mar 02, 2011 7:20 am

Re: Bromelain: Effect on amoxicillin?

Post by Helico_expert » Thu Feb 28, 2019 10:33 pm

it's interesting.. however i have no experience on it. Since it's no harm, you can go ahead and try it.

eliuri
Posts: 11
Joined: Tue Feb 19, 2019 8:10 am

Re: Bromelain: Effect on amoxicillin?

Post by eliuri » Fri Mar 01, 2019 2:07 am

Thanks...My concern is that it might increase Amoxicillin levels in the blood, as the research suggests it might. They dont however say by how much. Often the term "potentiate" is used instead..which sounds better

Helico_expert
Site Admin
Posts: 3507
Joined: Wed Mar 02, 2011 7:20 am

Re: Bromelain: Effect on amoxicillin?

Post by Helico_expert » Fri Mar 01, 2019 7:37 am

Amoxicillin is pretty safe. Very little side effect and can use in high dose. Prof Marshall usually prescribe 3g a day.

Post Reply

Return to “Antibiotics and Acid Pump Blockers”