Risk of Gastric cancer from PPIs?

The various unpleasant manifestations of Helicobacter can be described here. Remember however that the great majority of persons with Hp have no symptoms that they are aware of and consider themselves normal.

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redheadj
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Risk of Gastric cancer from PPIs?

Post by redheadj » Thu Jun 27, 2019 6:46 am

Hey, found this study from Hong Kong about the use of PPIs on patients diagnosed with HP and the increased chance of developing GC. Is this true? Rather worried and thinking of stopping my PPIs

https://gut.bmj.com/content/67/1/28

Helico_expert
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Re: Risk of Gastric cancer from PPIs?

Post by Helico_expert » Thu Jun 27, 2019 9:59 am

The title is a bit misleading.

If you read the data carefully, you can see that people without H pylori, there is little gastric cancer from patients who take long term PPI.

For patients with H pylori infection, the gastric cancer rate is already higher than those that are not infected. So this study basically showed that even eradicate of H pylori, there is still risk of Gastric cancer.
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